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The current definition of oxidative stress OS is an abnormal level of reactive oxygen-nitrogen species leading to cellular injury, which can be prevented by antioxidant AOX intake providing a therapeutic advantage. When this delicate balance is perturbed, homeostasis is compromised and disease may develop.
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Extensive research has shown a strong correlation with these events. Springer has been a leader in publishing books related to oxidative stress since The goal of the Oxidative Stress in Basic Research and Clinical Practice series is to present data showing relationships between OS and biomarkers, as well as results from clinical trials illustrating the efficacy of AOX supplementation.
Each volume covers a medical specialty, or major disease known to be associated with an imbalance between free radical production and AOX defense.
The expectation of the series is to critically evaluate the potential of AOXs in therapeutic intervention using simple and sophisticated methodology that could be adapted to point-of-care testing for diagnosis, intervention strategies and prognosis. We aim to identify molecular mechanisms modulated by ROS during spermatogenesis, epididymal sperm maturation and capacitation.
We recently characterized a newly discovered family of antioxidant enzymes called Peroxiredoxins PRDXs that play a major role in the protection of human spermatozoa against OS.
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Reduced activity or absence of PRDXs are associated with male infertility. Our ultimate goal is to develop novel diagnostic and therapeutic approaches to help infertile men.
Click on to see my current publications list. Low amounts and high thiol oxidation of peroxiredoxins in spermatozoa from infertile men. J Androl, , Hydrogen peroxide modifies human sperm peroxiredoxins in a dose-dependent manner.
Biol Reprod , Sperm capacitation as an oxidative event. In: "Studies on men's health and fertility, oxidative stress in applied basic research and clinical practice".
Humana Press, Springer Science, pp O'Flaherty C.