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A related article has been published: Vaccine therapy in hematologic malignancies. A related article has been published: Chimeric antigen receptor—modified T cells: CD19 and the road beyond. A related article has been published: Introduction to a review series on emerging immunotherapies for hematologic diseases. Contribution: L.
Postdoctoral Researcher - Molecular Cellular Therapeutics | EURAXESS
Hematopoietic cell transplantation HCT -specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Design and validation of an augmented hematopoietic cell transplantation-comorbidity index comprising pretransplant ferritin, albumin, and platelet count for prediction of outcomes after allogeneic transplantation. Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment. Radiolabeled anti-CD45 antibody with reduced-intensity conditioning and allogeneic transplantation for younger patients with advanced acute myeloid leukemia or myelodysplastic syndrome.
Biodistributions, myelosuppression, and toxicities in mice treated with an anti-CD45 antibody labeled with the alpha-emitting radionuclides bismuth or astatine Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
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Preincubation of donor bone marrow cells with a combination of murine monoclonal anti-T-cell antibodies without complement does not prevent graft-versus-host disease after allogeneic marrow transplantation. Quantitative assays for detection of residual T cells of T-depleted human marrow.
T cell depletion of donor marrow for prevention of acute graft-versus-host disease.
Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Transplantation of HLA-mismatched marrow depleted of T-cells by lectin agglutination and E-rosette depletion. Evaluation of HLA-haplotype disparate parental marrow grafts depleted of T lymphocytes by differential agglutination with a soybean lectin and E-rosette depletion for the treatment of severe combined immunodeficiency. Rapid recovery of helper activity following T cell depleted allogeneic marrow transplant. Recovery of immunoglobulin isotypes following T-cell depleted allogeneic bone marrow transplantation.
Immunological reconstitution after bone marrow transplant with Campath-1 treated bone marrow.
Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: importance of a graft-versus-leukaemia effect. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants. Improved outcome with T-cell-depleted bone marrow transplantation for acute leukemia. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype.
Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease. Ex vivo T cell-depleted versus unmodified allografts in patients with acute myeloid leukemia in first complete remission. T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin.
New approaches to graft engineering for haploidentical bone marrow transplantation. Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor.
Prof. Wolfgang Holter, MD
Di Stasi. Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene. Improving the safety of T-Cell therapies using an inducible caspase-9 gene. Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation.
Al Malki. Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Haploidentical stem cell transplantation augmented by CD45RA negative lymphocytes provides rapid engraftment and excellent tolerability. Rapid memory T-cell reconstitution recapitulating CD45RA-depleted haploidentical transplant graft content in patients with hematologic malignancies.
Molecular and Cellular Therapeutics
Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. Favorable impact of pre-transplant ATG on outcomes of reduced-intensity hematopoietic cell transplants from partially mismatched unrelated donors. Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide.
Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant.
Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Activation of thymic regeneration in mice and humans following androgen blockade. FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche. Impaired thymopoiesis predicts for a high risk of severe infections after reduced intensity conditioning without anti-thymocyte globulin in double umbilical cord blood transplantation.
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. An early-biomarker algorithm predicts lethal graft-versus-host disease and survival. A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study. Etanercept plus topical corticosteroids as initial therapy for grade one acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Vander Lugt. ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.
Plasma elevations of tumor necrosis factor-receptor-1 at day 7 postallogeneic transplant correlate with graft-versus-host disease severity and overall survival in pediatric patients.
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A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality. The Biomarker Working Group Report. Hand grip strength and 2-minute walk test in chronic graft-versus-host disease assessment: analysis from the Chronic GVHD Consortium. Assessing response of therapy for acute and chronic graft-versus-host disease. Chronic graft-versus-host disease: implications of the National Institutes of Health consensus development project on criteria for clinical trials.
Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. A combined biomarker and clinical panel for chronic graft versus host disease diagnosis. The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease.
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation? Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.